Dr Stephen Wren

Article

Scanlon, James J, Bristow, Aidan P, Chioni, Athina-Myrto and Wren, Stephen P (2024) KISS1R antagonism as a promising anti-cancer approach : an overview on function, molecular mechanisms and therapeutic potential. Journal on Oncology, ISSN (print) 2692-563X

Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James (2024) Design and preparation of a fluorescent molecularly imprinted membrane for the selective detection of pepsin enzyme as a biomarker for gastroesophageal reflux disease. Talanta Open, p. 100351. ISSN (online) 2666-8319 (Epub Ahead of Print)

Steverding, Dietmar, Tinson, Ryan A.J., Piras, Monica, Wren, Stephen, Rushworth, Stuart A., Searcey, Mark and Troeberg, Linda (2024) Suramin : effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug. Experimental Parasitology, 260, p. 108744. ISSN (print) 0014-4894

Mostafa Mohamed, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James (2024) Development of highly sensitive fluorescent sensors for separation-free detection and quantitation systems of pepsin enzyme applying a structure-guided approach. Biosensors, 14(3), p. 151. ISSN (online) 2079-6374

Long, N., Le Gresley, A., Wozniak, A., Brough, S. and Wren, S. (2024) Synthesis and evaluation of druglike parameters via 'in silico' techniques for a series of heterocyclic monosquarate-amide derivatives as potential carboxylic acid bioisosteres. Bioorganic & Medicinal Chemistry, 98, p. 117565. ISSN (print) 0968-0896

Green, Jonathan, Tinson, Ryan A.J., Betts, Jacob H.J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen P., Searcey, Mark and Troeberg, Linda (2023) Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue. Bioorganic & Medicinal Chemistry, 92, p. 117424. ISSN (print) 0968-0896

Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve and Wren, Stephen Paul (2023) Synthesis of squaric acid monoamides as building blocks for drug discovery. SynOpen, ISSN (online) 2509-9396 (In Press)

Mohamed, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James (2022) Development of magnetic molecularly imprinted polymers for the extraction of salivary pepsin prior to analysis by a novel HPLC-SEC method. Polymer, 261, p. 125417. ISSN (print) 0032-3861

Araar, Islam M and Wren, Stephen P (2022) A computational chemistry-driven hypothesis on the mode of action of hipposudoric acid and related analogs. Future Medicinal Chemistry, ISSN (print) 1756-8919 (Epub Ahead of Print)

Benardout, Miles, Le Gresley, Adam, ElShaer, Amr and Wren, Stephen P. (2022) Fructose malabsorption : causes, diagnosis and treatment. British Journal of Nutrition, 127(4), pp. 481-489. ISSN (print) 0007-1145

Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James (2021) Review on molecularly imprinted polymers with a focus on their application to the analysis of protein biomarkers. TrAC Trends in Analytical Chemistry, 144, p. 116431. ISSN (print) 0165-9936

Paulsson-Habegger, Lukas, Snabaitis, Andrew K. and Wren, Stephen P. (2021) Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection. Bioorganic & Medicinal Chemistry, 48, p. 116389. ISSN (print) 0968-0896

Long, Nathan, Le Gresley, Adam and Wren, Stephen (2021) Thiazolidinediones : an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus. ChemMedChem, 16(11), pp. 1717-1736. ISSN (print) 1860-7179

Vink, Guillaume, Nebel, Jean-Christophe and Wren, Stephen P (2021) In silico design of bioisosteric modifications of drugs for the treatment of diabetes. Future Medicinal Chemistry, 13(8), pp. 691-700. ISSN (print) 1756-8919

Scanlon, James J. and Wren, Stephen (2020) Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres. Future Medicinal Chemistry, 12(20), pp. 1855-1864. ISSN (print) 1756-8919

Ritchie, James, Sykes, Andy, Weber, Peter and Wren, Stephen P. (2019) Immuno-oncology : the next generation of breakthrough therapies. Highlights from The Society for Medicines Research Symposium. Oxford, UK - June 21, 2019. Drugs of the Future, 44(7), pp. 599-604. ISSN (print) 0377-8282

Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D., Bambridge, Gabriel, Wren, Stephen P., Nagase, Hideaki and Troeberg, Linda (2017) Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3. Molecular Pharmacology, 92(4), pp. 459-468. ISSN (print) 0026-895X

Wren, Stephen P., Piletsky, Sergey A., Karim, Kal, Gascoine, Paul, Lacey, Richard, Sun, Tong and Grattan, Kenneth T. V. (2015) Computational design and fabrication of optical fibre fluorescent chemical probes for the detection of cocaine. Journal of Lightwave Technology, 33(12), pp. 2572-2579. ISSN (print) 0733-8724

Zangeneh Kamali, Khosro, Pandikumar, Alagarsamy, Sivaraman, Gandhi, Lim, Hong Ngee, Wren, Stephen Paul, Sun, Tong and Huang, Nay Ming (2015) Silver@graphene oxide nanocomposite-based optical sensor platform for biomolecules. RSC Advances, 5(23), pp. 17809-17816. ISSN (online) 2046-2069

Wren, Stephen P., Nguyen, T. Hien, Gascoine, Paul, Lacey, Richard, Sun, Tong and Grattan, Kenneth T.V. (2014) Preparation of novel optical fibre-based cocaine sensors using a molecular imprinted polymer approach. Sensors and Actuators B: Chemical, 193, pp. 35-41. ISSN (print) 0925-4005

Book Section

Wren, Stephen P. (2022) Tricyclic systems : central carbocyclic ring with fused five- and six-membered rings. In: Aldabbagh, Fawaz, (ed.) Comprehensive Heterocyclic Chemistry IV. Amsterdam : Elsevier. pp. 1003-1019. 10 ISBN 9780128186565