Professor Adam Le Gresley
Faculties, deparments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Chemical and Pharmaceutical Sciences
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Faculty Research and Knowledge Exchange Lead/School Director of Research and Enterprise
- Email:
- a.legresley@kingston.ac.uk
About
I obtained my PhD from the University of Surrey in 2004, working under Professor Nikolai Kuhnert on the synthesis of Calix[4]arene derivatives for dynamic combinatorial libraries. I undertook my postdoctoral work as an NIH Research Fellow at Drexel College of Medicine in the USA, where I worked on the synthesis and evaluation of "caged" compounds for probing biological pathways in the brain.
Since joining Kingston University in 2009, I have established a research group in organic and analytical chemistry, funded by industrial sponsors such as GlaxoSmithKline, LGC Ltd and Innovate UK, working on the design and synthesis of fluorogenic compounds for problem pathogen detection and method development for NMR metabolomics/2D qNMR for complex mixture analysis and metrology. I have collaborations with institutions in Germany, Australia and the USA.
Contact Details:
Address: PRMB1002, Kingston University, London, KT1 2EE
Tel: +44 (0)208 4177432
Email: a.legresley@kingston.ac.uk
Qualifications
- 2009-2010: Postgraduate Certificate in Higher Education - Kingston University.
- 2000-2004: PhD in Organic and Supramolecular Chemistry - University of Surrey.
- 1996-2000: BSc(Hons) Chemistry with a Industrial Placement - University of Surrey.
Domains
Online Lectures for Lecturio GmbH, an online medical course.
Courses taught
My team currently consists of the following excellent researchers;
- 2D NMR techniques for Oral Health products - funded by GSK - PostDoc - Dr Cameron Robertson
- 2D NMR techniques for formulation characterisation and quantitation - funded by GSK- PostDoc - Dr Tomris Coban
- Novel organic peroxide synthesis and evaluation - funded by GSK - PhD Student - Grace Broadberry
- Water soluble polymer analysis and biological evaluation of impact in river water - funded by BBSRC/GSK iCASE Award - PhD Student - Drishna Sainju
- Probing complex formulation gels with Solid state NMR -funded by Haleon PLC - - PhD Student -Samah Hassan
I am also involved in a number of cross-faculty research projects aided by UG/PG project students.
Alumni
- Dr Gilbert Ampem
- Dr Alex Fudger
- Postdoc - Dr Matteo Zecchini
- Dr Tomris Coban
- Dr Cameron Robertson
- Dr Luke Bywaters
- Dr Samerah Malik
- Dr Fahmina Fardus
- Dr Baljeet Kaur
Specialisms
- Organic Chemistry
- NMR
- Skin Science
- Food Chemistry
Scholarly affiliations
- Fellow of the Royal Society of Chemistry
- Fellow of the Higher Education Academy
Industry links
- GlaxoSmithKline
- LGC Ltd
University responsibilities
- School Director of Research and Enterprise
Public and Civic roles
- Director North Lane Management Company
Publications
Effectiveness of different antioxidants in suppressing the evolution of thermally induced peroxidation products in hemp seed oil
Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Patrick Naughton, Declan, 2024, Food Research International (188), pp 114415
Modified PSYCHE NMR - the possibility for the direct semi-quantitation of components in mixtures
Durrant, Arija, Peron, Jean-Marie R., Langat, Moses K., Robertson, Cameron and Le Gresley, Adam, 2024, Talanta (268), 1, pp 125332
Suppressing thermo-induced peroxidation products in peroxidatively-susceptible frying oils by the employment of culinary oil blend formulations
Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin and Naughton, Declan Patrick, 2024, Journal of Food Composition and Analysis (125), pp 105747
Synthesis and evaluation of druglike parameters via 'in silico' techniques for a series of heterocyclic monosquarate-amide derivatives as potential carboxylic acid bioisosteres
Long, N., Le Gresley, A., Wozniak, A., Brough, S. and Wren, S., 2024, (98), pp 117565
Evaluation of nuclear magnetic resonance spectroscopy for characterisation and quantitation of water-soluble polymers in river water
Sainju, Drishna, Lucas, Robert and Le Gresley, Adam, 2023, Water Research (245), pp 120650
Synthesis of squaric acid monoamides as building blocks for drug discovery
Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve and Wren, Stephen Paul, 2023, SynOpen
High-resolution 1H NMR analysis of continuous and discontinuous thermo-oxidative susceptibility of culinary oils during frying at 180℃
Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P, 2023, Journal of Food and Drug Analysis (31), 1, pp 95-115
Chemical synthesis of a library of natural product-like derivatives based on pinnaic acid and initial evaluation of their anti-cancer activity
Fudger, Alex, Cakir, Okan M., Khan, Yousaf, Sinclair, Alex and Le Gresley, Adam, 2022, (47), 20, pp 9408-9421
Nuclear magnetic resonance spectroscopic analysis of the evolution of peroxidation products arising from culinary oils exposed to thermal oxidation : an investigation employing ¹H and ¹H-¹H COSY and TOCSY techniques
Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P., 2022, Foods (11), 13, pp 1864
Investigation of the formation of squalene oligomers exposed to ultraviolet light and changes in the exposed squalene as a potential skin model
Zecchini, Matteo, Lucas, Robert A., Robertson, Cameron, Coban, Tomris, Thatti, Ravtej and Le Gresley, Adam, 2022, Molecules (27), 11, pp 3481
The impact of partial oil substitution and trace metal ions on the evolution of peroxidation products in thermally stressed culinary oils
Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin, De Mars, Simon and Naughton, Declan P., 2022, Food Chemistry (375), pp 131823
Fructose malabsorption : causes, diagnosis and treatment
Benardout, Miles, Le Gresley, Adam, ElShaer, Amr and Wren, Stephen P., 2022, British Journal of Nutrition (127), 4, pp 481-489
A proof-of-concept study utilising 2D NMR spectrometry for in situ characterisation and quantitation of key biomarkers and actives in tape stripped ex vivo human skin
Robertson, Cameron, Raj, Nidhin, Lucas, Robert, Coban, Tomris and Le Gresley, Adam, 2022, Talanta (237), pp 122980
The role of polydimethylsiloxane in suppressing the evolution of lipid oxidation products in thermo-oxidised sunflower oil : influence of stirring processes
Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P., 2021, Frontiers in Nutrition (8), pp 721736
Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)
Goenaga Infante, Heidi, Warren, John, Chalmers, John, Dent, Geoffrey, Todoli, Jose Luis, Collingwood, Joanna, Telling, Neil, Resano, Martin, Limbeck, Andreas, Schoenberger, Torsten, Hibbert, D. Brynn, LeGresley, Adam, Adams, Kristie and Craston, Derek, 2021, Pure and Applied Chemistry (93), 6, pp 647-776
Thiazolidinediones : an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus
Long, Nathan, Le Gresley, Adam and Wren, Stephen, 2021, ChemMedChem (16), 11, pp 1717-1736
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard and LeGresley, Adam, 2021, RSC Medicinal Chemistry (5), pp 751-757
Sunscreens containing cyclodextrin inclusion complexes for enhanced efficiency : a strategy for skin cancer prevention
Dahabra, Layan, Broadberry, Grace, Le Gresley, Adam, Najlah, Mohammad and Khoder, Mouhamad, 2021, Molecules (26), 6, pp 1698
"Real-world" evaluation of lipid oxidation products and trace metals in French fries from two chain fast-food restaurants
Le Gresley, Adam, Ampem, Gilbert, De Mars, Simon, Grootveld, Martin and Naughton, Declan P., 2021, Frontiers in Nutrition (8), pp 620952
Determination of metabolic activity in planktonic and biofilm cells of Mycoplasma fermentans and Mycoplasma pneumoniae by nuclear magnetic resonance
Awadh, Ammar A., Le Gresley, Adam, Forster-Wilkins, Gary, Kelly, Alison F. and Fielder, Mark D., 2021, Scientific Reports (11), pp 5650
Synthesis and initial evaluation of a novel fluorophore for selective FMDV 3C Protease detection
Malik, Samerah, Sinclair, Alex, Ryan, Ali and Le Gresley, Adam, 2020, Molecules (25), 16, pp 3599
Evaluations of the peroxidative susceptibilities of cod liver oils by a ¹H NMR analysis strategy : peroxidative resistivity of a natural collagenous and biogenic amine-rich fermented product
Percival, Benita C., Wann, Angela, Zbasnik, Richard, Schlegel, Vicki, Edgar, Mark, Zhang, Jie, Ampem, Gilbert, Wilson, Philippe, Le Gresley, Adam, Naughton, Declan and Grootveld, Martin, 2020, Nutrients (12), 3, pp 753
Scope and limitations of nuclear magnetic resonance techniques for characterisation and quantitation of vitamin D in complex mixtures
Robertson, Cameron, Lucas, Robert A. and Le Gresley, Adam, 2020, Skin Research and Technology (26), 1, pp 112-120
Synthesis and spectral properties of novel Singapore Green analogues for protease detection
Bywaters, Luke and Le Gresley, Adam, 2020, Scientific Reports (10), pp 259
Characterisation of peroxidation products arising from culinary oils exposed to continuous and discontinuous thermal degradation processes
Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin, Percival, Benita C. and Naughton, Declan P., 2019, Food and Function (10), pp 7952-7966
New insights into the cystine-sulfite reaction
Zecchini, Matteo, Lucas, Robert and Le Gresley, Adam, 2019, Molecules (24), 13, pp 2377
Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil
Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean-Marie, Robinson, Joshua and O'Leary, Shane, 2019, Journal of Analytical and Applied Pyrolysis (140), pp 281-289
A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis
Le Gresley, Adam and Peron, Jean-Marie R., 2019, Food Chemistry (275), pp 385-389
Biological activities for 'Ficus carica' latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers
Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana and Ashrafi, G. Hossein, 2019, Scientific Reports (9), 1013
A life cycle assessment of options for producing synthetic fuel via pyrolysis
Vienescu, D.N., Wang, J., Le-Gresley, A. and Nixon, J.D., 2018, Bioresource Technology (249), pp 626-634
Fatty acid based microemulsions to combat ophthalmia neonatorum caused by 'Neisseria gonorrhoeae' and 'Staphylococcus aureus'
Butt, Ummara, ElShaer, Amr, Snyder, Lori A. S., Al-Kinani, Ali A., Le Gresley, Adam and Alany, Raid G., 2018, Nanomaterials (8), 1, pp 51
Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of 'Staphylococcus aureus'
Bywaters, Luke, Mulcahy-Ryan, Lauren, Fielder, Mark, Sinclair, Alex and Le Gresley, Adam, 2017, Molecular and Cellular Probes (36), pp 1-9
Validating heteronuclear 2D quantitative NMR
Fardus-Reid, Fahmina, Warren, John and Le Gresley, Adam, 2016, Analytical Methods (8), 9, pp 2013-2019
Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents.
Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E, 2016, (14), pp 3069-3079
The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries
Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert, 2015, Analytical Methods (7), 6, pp 2323
Bias and uncertainty in non-ideal qNMR Analysis
Le Gresley, Adam, Fardus, Fahmina and Warren, John, 2015, Critical reviews in analytical chemistry / CRC (45), 4, pp 300-10
Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments.
Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam, 2013, (11), 20, pp 3307-3313
The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction
Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam, 2012, Tetrahedron Letters (53), 33, pp 4280-4282
The application of high resolution diffusion NMR to the analysis of manuka honey
Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D, 2012, Food Chemistry (135), 4, pp 2879-86
Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays
Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza, Lafon, Shehri and Sinclair, Alex, 2011, MedChemComm (2), 6, pp 466-470
Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands
Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri, 2010, Synthetic Communications (41), 16, pp 2483-2492
The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries
Le-Gresley, A and Kuhnert, N, 2010, Journal of Chemical Research (2), pp 61-67
Synthesis of upper rim calix[4]arene carcerands
Kuhnert, Nikolai and Le Gresley, Adam, 2008, Tetrahedron Letters (49), 7, pp 1274-1276
Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer
Kuhnert, Nikolai, Le Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana, 2007, Journal of Labelled Compounds and Radiopharmaceuticals (50), 13, pp 1215-1223
Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes
Kuhnert, Nikolai and Le Gresley, Adam, 2005, (3), 11, pp 2175-2182
The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries
Kuhnert, Nikolai and Le-Gresley, Adam, 2005, Tetrahedron Letters (46), 12, pp 2059-2062
The synthesis of tetra-acrylamido-calix[4]arene capsules
Kuhnert, Nikolai and Le-Gresley, Adam, 2003, Chemical Communications (19), pp 2426-2427
On the scope and limitations of the Heck reaction of upper rim tetraiodocalix[4]arenes
Kuhnert, Nikolai and Le Gresley, Adam, 2001, Perkin Transactions 1 (24), pp 3393-3398
Bicyclic 5-5 systems : five heteroatoms 2:3 and six heteroatoms 3:3
Le Gresley, Adam (2022). In: Al-dabbagh, Fawaz, (ed.), Comprehensive Heterocyclic Chemistry IV. Amsterdam: Elsevier, pp 120-134
Quantification and identification of compounds by qNMR and a quantitative PSYCHE NMR method
Durrant, Arija, Peron, Jean-Marie R, Le Gresley, Adam and Langat, Moses K(2023). In: The 19th European Nuclear Magnetic Resonsance Congress (EuroMar 2023), 9-13 July 2023 :Glasgow, U.K.
Identification and quantification of isolated medicinal compounds by PSYCHE NMR and DOSY NMR
Durrant, Arija, Peron, Jean-Marie, Le Gresley, Adam and Langat, Moses(2022). In: Ampere NMR School 2022, 19-25 Jun 2022 :Zakopane, Poland
Optimization and uncertainty budgets of externally standardised NMR assays
Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie(2011). In: Bruker MR Users' Meeting 2011, 15-16t Nov 2011 :Coventry, UK
The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR
Le Gresley, Adam, Gollapalli, Uma and Ghosh, Uttam(2009). In: National Cancer Research Institute Cancer Conference, 04 -07 Oct 2009 :Birmingham, U.K.
The synthesis of novel calix[4]arene tetra-acrylates and their potential use as macrocyclic platforms in the development of static and dynamic combinatorial libraries using reversible imine formation.
Le Gresley, Adam and Kuhnert, Nikolai(2009). In: IUPAC Conference, Glasgow, UK
Gallery of work
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EUChems Conference, Seville, 2016
Nobel Prize Winner Prof Jean-marie Lehn and Dr Adam Le Gresley
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Cameron Robertson at Conference Leeds University, 2018
,RSC Biophysical Chemistry Conference
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Dr Fahmina Fardus at PhD Graduation
Kingston University, 2017
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Tomris Coban presenting at KU Symposium
Drug Discovery and Synthesis Symposium, 2019, Kingston University
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Grace Broadberry presenting her NMR work
Drug discovery and synthesis symposium, Kingston University. 2019
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PhD Viva as External Examiner - Jacobs University, Bremen, Germany
Dr. Seung-Hun Lee with Prof. Dr. Nikolai Kuhnert and Dr. Adam Le Gresley
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Team LGX from 2014
Left to right: Dr Lauren Mulcahey-Ryan, Dr Alex Sinclair, Prof Mark Fielder and Dr Adam Le Gresley
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Le Gresley Group - Virtual Escape the room - 2021 - The case of the Eastside strangler
Clockwise from the left Grace Broadberry, Gilbert Ampem, Dr Cameron Robertson, Dr Tomris Coban and Prof Adam Le Gresley. Missing are Alex Fudger and Arija Lowe
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First Graduation Ceremony since Covid - Dr Coban and Dr Robertson
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Arija Durrant at the Ampere Conference
Presenting on qPSYCHE in Zakopane, Poland
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Dr Cameron Robertson discussing KASNMR industrial collaboration 2022
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Dr Cameron Robertson - RSC Biomaterials Chemistry Interest Group 2023 Meeting
RSC Biomaterials Chemistry Interest Group, 2023, Sheffield, UK
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Dr Tomris Coban - RSC Biomaterials Chemistry Interest Group 2023 Meeting
RSC Biomaterials Chemistry Interest Group, 2023, Sheffield, UK
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Drishna Sainju
Euromar, Glasgow, 2023
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Dr Gilbert Ampem Graduation
Prof Declan Naughton and Dr Gilbert Ampem, Rose Theatre, July 2023
