Dr Sianne Schwikkard
Faculties, deparments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Chemical and Pharmaceutical Sciences
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Senior lecturer
- Email:
- s.schwikkard@kingston.ac.uk
About
I completed my PhD in Natural Products Chemistry at the University of Kwazulu-Natal, South Africa in 1998. The complexity and beauty of natural compounds fascinated me and has led to a life-long pursuit of both novel compounds from plant sources as well as the synthesis of these compounds. Plants can produce a range and diversity of chemical entities unparalleled by synthetic efforts and displaying an unsurprising range of biological activities. My research career was developed through a post-doctoral fellowship at Virginia Tech under Professor David Kingston, followed by a post-doctoral position at the Rand Academic University under Professor Fanie Van Heerden. I spent a short 18 months working in the petrochemical industry for Sasol Technology before relocating to the UK and working for Professor Keith Jones at Kingston University.
I spent 11 years as a part-time lecturer at Kingston University and research associate at Surrey University before I joined Kingston University full time in September 2015.
While at the University of Surrey, I was awarded a Daphne Jackson Fellowship and I have maintained links with the Daphne Jackson Trust.
Qualifications
- PhD (Natural Products, University of Kwazulu-Natal, South Africa)
- MSc
- BSc (Hons)
- BSc
- AFHEA
- FHEA
Domains
My background in natural products and synthetic organic chemistry has allowed me the opportunity to teach across all three departments in the School of Life Sciences, Pharmacy and Chemistry. This had given me an appreciation for the challenges faced by students across the school.
Having lived and worked in three different countries in very different parts of the world (South Africa, America and UK) gives me a broad experience and sympathy for students from a diverse range of backgrounds, facing a diverse range of challenges in their education.
Having completed the AFHEA and the FHEA has provided me with the necessary skills to engage and challenge different students with different educational needs.
I was the lead for the Personal Tutor Scheme for the Department of Chemistry and Pharmaceutical Science from 2018-2023. The personal and tailored support a personal tutor can provide for a student has a positive impact on their university experience and can significantly impact on their academic success. In addition it is essential that the academic staff acting as personal tutors have adequate support as the role can be challenging. It was my privilege to work with colleagues across the department to develop an excellent program of support for our students.
Keeping on the fore front of my research field positively impacts on my teaching as I am better able to inspire my students with relevant and novel research in their chosen fields of study. Teaching should always include cutting edge research in the field to ensure that students are aware of new developments and challenges.
I am currently admissions tutor for the Department of Chemical and Pharmaceutical Sciences and work closely with our recruitment and outreach team. In addition I have established a collaboration with the EDT (Engineering Development Trust). This is an organisation working to promote STEM subjects and encourage school leavers to consider STEM careers. This has allowed our staff to deliver workshops and lectures to school leavers throughout the UK.
Qualifications
- AFHEA
- FHEA
Courses taught
I have an interest in bioactive natural products, both isolated from plant sources as well as their synthetic analogues. My two main areas of research are eye diseases characterised by neovascularisation and the development of new drugs targeting drug resistant bacteria. I have a particular interest in compounds known as homoisoflavonoids, isolated primarily from the Hyacinthaceae (Asparagaceae). These compounds have a range of interesting biological activities including anti-cancer, anti-inflammatory and anti-angiogenic effects. They have been identified as potential new sources of treatment for macular degeneration and other eye diseases characterised by angiogenesis.
My work on macular degeneration is carried out in collaboration with the University of Surrey and the Glick Eye Institute, University of Indiana. The work has been highlighted by this article in the Daily mail:
https://www.dailymail.co.uk/health/article-6903127/Hyacinths-lead-cure-blindness-scientists-say.html
In addition, I am collaborating with Professor Raid Alany and Dr Ali Al-Kinani to look at the effect of these compounds on diseases of the cornea.
Together with Dr Alison Kelly of Kingston University (microbiology) we are investigating the effect of natural products and synthetic analogues of natural products on antibiotic resistant bacteria. We are looking at compounds isolated from East African Croton species as well as curcumin and piperidone derivatives.
An ongoing and highly productive collaboration with the Jodrell laboratory and the Royal Botanical gardens, Kew has allowed me to investigate interesting and under researched plant species as well as allowing my students to experience this world class laboratory.
I am first supervisor for 2 PhD students and 1 MRes student and second supervisor for 3 PhD students. I have 2 completions for MSc by research as first supervisor and 1 as second supervisor as well as 3 PhD completions as second supervisor (University of Surrey and Kingston University) and 1 as first supervisor.
Qualifications
- Natural Products Chemistry
- Synthesis of Natural products
- Chromatography
- Spectroscopy
Specialisms
- Natural products Chemistry
- Synthesis of Natural products
- Chromatography
- Spectroscopy
Scholarly affiliations
- MRSC
I am currently serving on the committee assessing the applications for the RSC Research Fund.
I have maintained links with the Daphne Jackson Trust and have given a number of talks at events they have organised on employability and getting people back to work in research after a career break. The Trust provides Fellowships for people who have had to take a career break to allow them to restart their research career. It provides vital opportunities for people to update their skills and allow them to complete on an equal playing field.
I am the Admissions Tutor for the Department of Chemical and Pharmaceutical Sciences.
University responsibilities
- Admissions Tutor for Department of Chemistry and Pharmaceutical Science
Publications
Crotoscheffleriolides, ent-clerodane diterpenoids from Kenyan Croton scheffleri
Diri, Mona, Langat, Moses K., Mas-Claret, Eduard, Prescott, Thomas A.K., Cruz, Cristina D., Tammela, Päivi and Schwikkard, Sianne, 2025, Phytochemistry, pp 114460
Diri, Mona, Cruz, Cristina D., Mas-Claret, Eduard, Sadgrove, Nicholas, Prescott, Thomas A. K., Langat, Moses K., Tammela, Päivi and Schwikkard, Sianne L., 2024, Natural Product Research
Review: The chemistry, toxicity and antibacterial activity of curcumin and its analogues
Denison, Hannah J., Schwikkard, Sianne L., Khoder, Mouhamad and Kelly, Alison F., 2023, Planta Medica
Sustained release ocular drug delivery systems for glaucoma therapy
Al-Qaysi, Zinah, Beadham, Ian, Schwikkard, Sianne, Bear, Joseph, Al-Kinani, Ali and Alany, Raid, 2023, Expert Opinion on Drug Delivery
Pharmacological treatment strategies of pterygium : drugs, biologics, and novel natural products
Baheran, Sanaz Sadig, Alany, Raid G., Schwikkard, Sianne, Muen, Wisam, Salman, Lena Namaan, Freestone, Nicholas and Al-Kinani, Ali A., 2022, Drug Discovery Today, pp 103416
Multi-layered antimicrobial synergism of (E)-caryophyllene with minor compounds, tecleanatalensine B and normelicopine, from the leaves of 'Vepris gossweileri' (I. Verd.) Mziray
Langat, Moses K., Mayowa, Yisau, Sadgrove, Nicholas, Danyaal, Mohammed, Prescott, Thomas A. K., Kami, Teva, Schwikkard, Sianne, Barker, James and Cheek, Martin, 2022, Natural Product Research (36), 10, pp 2447-2457
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard and LeGresley, Adam, 2021, RSC Medicinal Chemistry (5), pp 751-757
The effect of isolates from 'Cassipourea flanaganii' (Schinz) alston, a plant used as a skin lightning agent, on melanin production and tyrosinase inhibition
Langat, Moses K., Dlova, Ncoza C., Mulcahy-Ryan, Lauren E., Schwikkard, Sianne L., Opara, Elizabeth I., Crouch, Neil R., Hiles, Jacob D. and Mulholland, Dulcie A., 2021, Journal of Ethnopharmacology (264), pp 113272
Bufadienolides and anti-angiogenic homoisoflavonoids from 'Rhodocodon cryptopodus', 'Rhodocodon rotundus' and 'Rhodocodon cyathiformis'
Whitmore, Hannah, Sishtla, Kamakshi, Knirsch, Walter, Andriantiana, Jacky L., Schwikkard, Sianne, Mas-Claret, Eduard, Nassief, Sarah M., Isyaka, Sani M., Corson, Timothy W. and Mulholland, Dulcie A., 2020, Fitoterapia (141), pp 104479
The antiangiogenic activity of naturally occurring and synthetic homoisoflavonoids from the Hyacinthaceae (sensu APGII)
Schwikkard, Sianne, Whitmore, Hannah, Sishtla, Kamakshi, Sulaiman, Rania S., Shetty, Trupti, Basavarajappa, Halesha D., Waller, Catherine, Alqahtani, Alaa, Frankemoelle, Lennart, Chapman, Andy, Crouch, Neil, Wetschnig, Wolfgang, Knirsch, Walter, Andriantiana, Jacky, Mas-Claret, Eduard, Langat, Moses K., Mulholland, Dulcie and Corson, Timothy W., 2019, Journal of Natural Products (82), 5, pp 1227-1239
Melanin production inhibitors from the West African 'Cassipourea congoensis'
Takou, Dieudonne M., Kamdem Waffo, Alain F., Langat, Moses K., Wansi, Jean D., Mulcahy-Ryan, Lauren E., Schwikkard, Sianne L., Opara, Elizabeth I., Mas-Claret, Eduard and Mulholland, Dulcie A., 2019, Planta Medica International Open (6), 2, pp e50-e56
Antiangiogenic activity and cytotoxicity of triterpenoids and homoisoflavonoids from 'Massonia pustulata' and 'Massonia bifolia'
Schwikkard, Sianne, Whitemore, Hannah, Corson, Timothy, Sishtla, Kamakshi, Langat, Moses K., Carew, Mark and Mulholland, Dulcie A., 2018, Planta Medica (84), pp 638-644
Diterpenoids from the roots of 'Croton dichogamus' Pax
Aldhaher, Areej, Langat, Moses, Ndunda, Beth, Chirchir, Denis, Midiwo, Jacob O., Njue, Alice, Schwikkard, Sianne, Carew, Mark and Mulholland, Dulcie, 2017, Phytochemistry (144), pp 1-8
Phytochemical investigations of three Rhodocodon (Hyacinthaceae Sensu APG II) species
Schwikkard, Sianne, Alqahtani, Alaa, Knirsch, Walter, Wetschnig, Wolfgang, Jaksevicius, Andrius, Opara, Elizabeth, Langat, Moses, Andriantiana, Jackie and Mulholland, Dulcie, 2017, Journal of Natural Products (80), 1, pp 30-37
Useful Methods for Targeted Plant Selection in the Discovery of Potential New Drug Candidates
Schwikkard, Sianne L. and Mulholland, Dulcie A., 2014, Planta Medica (80), 14, pp 1154-1160
The chemistry and biological activity of the Hyacinthaceae
Mulholland, Dulcie A., Schwikkard, Sianne L. and Crouch, Neil R., 2013, Natural Product Reports (30), 9, pp 1165-1210
The effect of aromatic ethers on the trimerisation of ethylene using a chromium catalyst and aryloxy ligands
Morgan, David H., Schwikkard, Sianne L., Dixon, John T., Nair, Jerald J. and Hunter, Roger, 2003, (345), 8, pp 939-942
Antimalarial activity of plant metabolites
Schwikkard, Sianne and van Heerden, Fanie R., 2002, Natural Product Reports (19), 6, pp 675-692
Delevoyin C, a tetranortriterpenoid from Entandrophragma delevoyi
Mulholland, Dulcie A., Schwikkard, Sianne L., Sandor, Peter and Nuzillard, Jean M., 2000, Phytochemistry (53), 4, pp 465-468
Limonoid derivatives from Astrotrichilia voamatata
Mulholland, Dulcie A., Randrianarivelojosia, Milijaona, Lavaud, Catherine, Nuzillard, Jean-Marc and Schwikkard, Sianne L., 2000, Phytochemistry (53), 1, pp 115-118
Bioactive Compounds from Combretum erythrophyllum
Schwikkard, Sianne, Zhou, Bing-Nan, Glass, Thomas E., Sharp, Jessica L., Mattern, Michael R., Johnson, Randall K. and Kingston, David G. I., 2000, Journal of Natural Products (63), 4, pp 457-460
Bioactive Compounds from Combretum erythrophyllum
Schwikkard, Sianne, Zhou, Bing-Nan, Glass, Thomas E., Sharp, Jessica L., Mattern, Michael R., Johnson, Randall K. and Kingston, David G. I., 2000, Journal of Natural Products (63), 7, pp 1045-1046
Limonoids from Astrotrichilia voamatata
Mulholland, Dulcie A., Schwikkard, Sianne L. and Randrianarivelojosia, Milijaona, 1999, Phytochemistry (52), 4, pp 705-707
Phaeophytins from Tapura fischeri
Schwikkard, Sianne L., Mulholland, Dulcie A. and Hutchings, Anne, 1998, Phytochemistry (49), 8, pp 2391-2394
Novel, bioactive homoisoflavonoids from a Madagascan Rhodocodon species (Hyacinthaceae, sensu APG II)
Schwikkard, S., James, E. E., Mulholland, D. A., Knirsch, W., Corson, T., Opara, E. and Jaksevicius, A.(2015). In: 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA2015), 23 - 27 Aug 2015 :Szeged, Hungary
Gallery of work
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Hyacinthaceae plant containing homoisoflavonoids
Plant investigated as part of the search for novel homoisoflavonoids
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Presenting in Kenya at the Newton Fund and UK Research Council Collaborative Conference 2017
The work on synthesis of bioactive homoisoflavonoid for the treatment of macular degneration
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Hannah Denison (PhD student) presenting at the GA conference in Dublin 2023
Poster Presentation (Hannah Denison, PhD student) on Antimicrobial Curcumin Derivatives at the GA Conference in Dublin 2023
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Kingston University, Surrey University and Collaborators from University of Indiana at Wisley Gardens 2023
Kingston University, Surrey University and Collaborators from University of Indiana at Wisley Gardens
