Dr Francesca Arrigoni
Faculties, deparments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Pharmacy
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Senior lecturer Physiology/Pharmacology
- Email:
- f.arrigoni@kingston.ac.uk
About
Dr Francesca Arrigoni is a Senior Lecturer at Kingston in the Department of Pharmacy at Kingston (ranked #1 in London, and top 10 in the UK for Pharmacy) and has close ties working with the Infection, Immunity and Rheumatology at GOSH, the institute of Child Health, UCL which is based in the Faculty of Population Health Sciences #12 globally for Clinical, Pre-clinical & Health and in Life Sciences. Prior to that, she gained her PhD and post-doctoral experience at UCL and completed her undergraduate degree at Glasgow University with several awards and distinctions (John Hunter Medal 2 consecutive years).
Since joining Kingston University, and completing my Post-Graduate Certificate in Education I have been shortlisted for the Times Higher Education Teaching excellence award - Outstanding Research Supervisor of the year 2017, have been awarded a Senior Fellowship of the Higher Education Academy in 2018 and been awarded a Kingston University Teaching fellowship.
I have a small research group which, as a result of a successful collaboration with UCL, aims to understand how chronic inflammation and the activation of your immune system can influence the health of your vasculature with diseases, that include HIV and also vasculitis with numerous publications in the field of endothelial and vascular physiology.
Qualifications
- PhD Pharmacology UCL
- BSc (Hons) Physiology Glasgow University
- Senior Fellowship Higher Education Authority
- PGCE
Domains
I gained my PGCE in 2007 and my SFHEA in 2018. Involved in postgraduate research, I wanted to develop those skills usually acquired at postgraduate level in an undergraduate science classroom. Collaborating using a CATALYST funded project, I adapted a Critical Thinking toolkit to deconstruct skills of ; deduction, inference, logic and assumption to disseminate across the science faculty.
Evidence of the improvement in student metacognitive abilities were presented at the 4th Horizons in STEM Higher Education 2019. Student pass rate in this module at first attempt rose to 93% in 2019/0, alongside improved module evaluations.
I am a Critical Thinking champion for the faculty of Science and have created an online module through a teaching platform (Canvas) to enable staff to design critical thinking programmes and also how to build activities with critical thinking as a core element.
The Critical thinking elements were commended in the internal subject review and accreditations of mPharmacy and Pharmaceutical sciences in 2018.
Critical thinking is now an activity flagged across the entire school (Organic chemistry, forensic science, pharmaceutical science, Pharmacy and Life sciences) and the Critical Thinking toolkit handbook is available across numerous faculties within the university (Nursing, Business) .
Developing and applying critical thinking to a diverse syllabus, I was awarded a highly competitive Kingston University teaching fellowship in 2020.
I have also designed modules and curricula to include immunology teaching in the Pharmaceutical Science course, accredited by the Academy of Pharmaceutical Sciences (APS) in 2018. I have also ensured that Immunology integrates with disciplines of chemistry, pharmacy and pharmaceutics, spiralling upwards in difficulty, for the mPharm degree,.
I have pushed the most able students to succeed by repeatedly seeking and being awarded competitive funding by the University's Access Working Group, and also applying for and being awarded independent funding from bodies such as The Physiological Society to fund the stipends of undergraduate students wishing to complete summer project laboratory work.
I was nominated for the Times Higher Education " Outstanding research Supervisor of the year award", by my students in 2017.
Qualifications
- Senior Fellow HEA
- PGCE
- Kingston University Learning and Teaching Fellow
Courses taught
I trained as an undergraduate in Physiology at the University of Glasgow and completed my PhD at UCL in Pharmacology. In the last 20 years I have concentrated on how the lining of the blood vessels, named the endothelium, contributes to cardiovascular health in clinical studies.
My research interests currently focus upon the interaction of the vascular endothelium with various leukocyte populations under settings of vascular dysfunction and inflammatory stress.
In 2016, I embarked upon a close collaboration with the Institute of Child Health, GOSH, UCL to investigate how HIV as a chronic inflammatory disease , could impact vascular function chronically. I am also currently on the team for the analysis of data for the ARROW, EARNEST and CHAPAS HIV trials, carried out at GOSH, Institute of Child Health, UCL.
I have visited HIV clinics in South Africa and the Africa Health Research Institute as part of my ongoing collaboration .
I have been awarded grant funding to investigate the influence of nitric oxide on monocytic motility. Other research projects investigate the role autoimmune diseases in children of infection on vascular disease. These projects benefit from active and productive collaborations at the GOSH, Institute of Child Health, UCL.
Qualifications
- PhD Pharmacology
- BSc Hons Physiology
Specialisms
- Immunology of HIV
- The Vascular Endothelium
- Cardiovascular Disease
- Inflammation and damage to the lining of blood vessels
Scholarly affiliations
- Member of the Physiological Society
- Member of the British Pharmacological Society
- Senior Research Associate (Honorary) Institute of Child Health, Great Ormond Street Hospital, UCL
I contribute to leadership and management in numerous supportive roles mentoring students and staff alike:
Roles and Responsabilities
- Aurora Leadership programme
- Champion of Critical Thinking in SEC, CPD courses
- Athena SWAN faculty group member
- Laboratory manager of primary cell culture & IRTL governance group
University responsibilities
- Athena SWAN faculty team
- Primary Cell culture manager in LSPC
Publications
Transdisciplinary science and art : how drawing and notebook creation improved student accessibility to complex scientific concepts
Arrigoni, Francesca, 2023, Physiology News Magazine, 133, pp 21-23
Impact of sub-optimal HIV viral control on activated T-cells : an earnest sub study
Arrigoni, Francesca I.F., Spyer, Moira, Hunter, Patricia, Alber, Dagmar, Kityo, Cissy, Hakim, James, Matubu, Allen, Olal, Patrick, Paton, Nicholas I., Walker, A. Sarah and Klein, Nigel, 2023, AIDS
Inflammatory pathways amongst people living with HIV in Malawi differ according to socioeconomic status
Kelly, Christine, Tingao, Willard, Alber, Dagmar, Hunter, Patricia, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Abner, Alejandro Garcia, Kamn'gona, Raphael, Sheha, Irene, Chammudzi, Mishek, Jambo, Kondwani, Mallewa, Jane, Rapala, Alicja, Mallon, Patrick W. G., Mwandumba, Henry, Klein, Nigel and Khoo, Saye, 2021, PLoS ONE (16), 8, pp e0256576
The impact of viraemia on inflammatory biomarkers and CD4 cell subpopulations in HIV-infected children in sub-Saharan Africa
Prendergast, A, Szubert, A, Pimundu, G, Berejena, C, Pala, P, Shonhai, A, Hunter, P, Arrigoni, F, Musiime, V, Bwakura-Dangarembizi, M, M, Musoke, P, Poulsom, H, Kihembo, M, Munderi, P, Gibb, D, Spyer, M, Walker, A and Klein, N, 2021, AIDS (35), 10, pp 1537-1548
Inflammatory phenotypes predict changes in arterial stiffness following antiretroviral therapy initiation
Kelly, Christine, Tinago, Willard, Alber, Dagmar, Hunter, Patricia, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Abner, Alejandro Garcia, Kamngona, Ralph, Sheha, Irene, Chammudzi, Mishek, Jambo, Kondwani, Mallewa, Jane, Rapala, Alicja, Heyderman, Robert S, Mallon, Patrick W G, Mwandumba, Henry, Walker, A Sarah, Klein, Nigel and Khoo, Saye, 2020, Clinical Infectious Diseases (71), 9, pp 2389-2397
Microvascular function in pre-eclampsia is influenced by insulin resistance and an imbalance of angiogenic mediators
Ghosh, Anshuman, Freestone, Nicholas S, Anim-Nyame, Nicholas and Arrigoni, Francesca I F, 2017, Physiological Reports (5), 8, pp e13185
Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis
Lambden, Simon, Kelly, Peter, Ahmetaj-Shala, Blerina, Wang, Zhen, Lee, Benjamin, Nandi, Manasi, Torondel, Belen, Delahaye, Matthew, Dowsett, Laura, Piper, Sophie, Tomlinson, James, Caplin, Ben, Colman, Lucy, Boruc, Olga, Slaviero, Anna, Zhao, Lan, Oliver, Eduardo, Khadayate, Sanjay, Singer, Mervyn, Arrigoni, Francesca and Leiper, James, 2015, Arteriosclerosis, Thrombosis, and Vascular Biology (35), 6, pp 1382-1392
Relationship between insulin resistance and circulating endothelial cells in pre-eclampsia.
Anim-Nyame, Nick, Ghosh, Anshuman, Freestone, Nicholas and Arrigoni, Francesca, 2015, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (31), 10, pp 788-791
Levels of circulating endothelial cells and colony forming units are influenced by age and dyslipidaemia
Fabbri-Arrigoni, Francesca I., Clarke, Lindsey, Wang, Guosu, Charakida, Marietta, Ellins, Elizabeth, Halliday, Neil, Brogan, Paul A., Deanfield, John E., Halcox, Julian P. and Klein, Nigel, 2012, Pediatric Research (72), 3, pp 299-304
Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy
Arrigoni, Francesca I, Matarin, Mar, Thompson, Pamela J, Michaelides, Michel, McClements, Michelle E, Redmond, Elizabeth, Clarke, Lindsey, Ellins, Elizabeth, Mohamed, Saifullah, Pavord, Ian, Hunt, David M, Moore, Anthony T, Halcox, Julian and Sisodiya, Sanjay M, 2011, European Journal of Human Genetics (19), 2, pp 131-137
The biology and therapeutic potential of the DDAH/ADMA pathway
Arrigoni, Francesca, Ahmetaj, Blerina and Leiper, James, 2010, Current Pharmaceutical Design (16), 37, pp 4089-4102
Endothelial injury and repair in systemic vasculitis of the young
Clarke, LA, Hong, Y, Eleftheriou, D, Shah, V, Arrigoni, Francesca, Klein, NJ and Brogan, PA, 2010, (62), 6, pp 1770-1780
Tumour cell adhesion of endothelial cell monolayer
Abdullah, A, Arrigoni, F and Freestone, N, 2010, Journal of Pharmacy and Pharmacology (62), 10, pp 1496-1498
Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction
Clarke, Lindsey, Shah, Vanita, Arrigoni, Francesca, Eleftheriou, D., Hong, Ying, Halcox, Julian, Klein, Nigel and Brogan, Paul, 2008, Journal Of Thrombosis And Haemostasis (6), 6, pp 1025-1032
Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation.
Nandi, Manasi, Leiper, James, Arrigoni, Francesca, Hislop, Alison, Vallance, Patrick and Haywoth, Sheila, 2006, Pediatric Research (59), 6, pp 767-772
Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype
Smith, Caroline L., Birdsey, Graeme M., Anthony, Shelagh, Arrigoni, Francesca I., Leiper, James M. and Vallance, Patrick, 2003, Biochemical and Biophysical Research Communications (308), 4, pp 984-989
Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia
Arrigoni, Francesca I., Vallance, Patrick, Haworth, Sheila G. and Leiper, James M., 2003, Circulation (107), 8, pp 1195-1201
all-trans-retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase
Achan, Vinod, Tran, Cam T.L., Arrigoni, Francesca, Whitley, Guy St.J., Leiper, James M. and Vallance, Patrick, 2002, Circulation Research (90), 7, pp 764-769
The Therapeutic Potential of Dimethylarginine Dimethylaminohydrolase–Mediated Regulation of Nitric Oxide Synthesis
Leiper, James, Arrigoni, Francesca and Ahmetaj, Blerina (2012). In: Abraham, David, (eds.), Handler, Clive, (eds.), Dashwood, Michael, (eds.) and Coghlan, Gerry, (eds.), Translational Vascular Medicine. London, U.K.: Springer Verlag, pp (II)61-(II)88
Pharmacy, poisons and plants : a transdisciplinary approach to learning pharmacology
Arrigoni, Francesca, Conway, Clare and Wyman, Angie(2023). In: BERA Annual Conference 2023, 12-14 Sep 2023 :Birmingham, U.K.
‘Sewing’ the seeds for transdisciplinary learning
Conway, Clare, Arrigoni, Francesca, Wyman, Angie and Messenger, Erin(2023). In: GLAD Symposium 2023 : Gathering ourselves, 8 Sep 2023 :London, U.K.
Learning pharmacological science in context using art
Arrigoni, Francesca and Conway, Clare(2023). In: Innovation and Updates in Teaching and Student Education across Physiology and STEM in the UK, 12-13 Apr 2023 :Leeds, U.K.
Putting STEAM into nursing teaching
Arrigoni, Francesca and Blackie, Carmel(2023). In: Innovation and Updates in Teaching and Student Education across Physiology and STEM in the UK, 12-13 Apr 2023 :Leeds, U.K.
Transdisciplinary teaching in physiology to improve creative thinking
Arrigoni, Francesca(2021). In: BERA (British Educational Research Association) Annual Conference, 13 - 16 Sep 2021 :Held online
Dimethylarginine dimethylaminohydrolase levels in blood outgrowth endothelial cells
Halliday, Loryn, Freestone, Nicholas and Arrigoni, Francesca(2021). In: Physiology 2021, 12-16 Jul 2021 :Held online
ADA2 expression and activity in blood outgrowth endothelial cells
Halliday, L., Brogan, P., Freestone, N. and Arrigoni, F.(2020). In: 3rd International Conference on Deficiency of Adenosine Deaminase 2 : Driving Toward Consensus, 17-19 Nov 2020 :Held online
Adenosine deaminase 2 restores the endothelial glycocalyx of blood outgrowth endothelial cells
Halliday, Loryn, Esposito, Giulia, Brogan, Paul, Freestone, Nicholas and Arrigoni, Francesca(2019). In: Future Physiology 2019 : Translating Cellular Mechanisms into Lifelong Health Strategies, 17-18 Dec 2019 :Liverpool, U.K.
Influence of adenosine deaminase 2, on the angiogenic function of blood outgrowth endothelial cells
Halliday, Loryn, Brogan, Paul, Freestone, Nicholas and Arrigoni, Francesca(2019). In: Pharmacology 2019, 15-17 Dec 2019 :Edinburgh, U.K.
Circulating microparticle levels in children following the initiation of antiretroviral therapy
Luckhurst, Natasha, Kenny, Julia, Hunter, Patricia, Freestone, Nicholas, Klein, Nigel and Arrigoni, Francesca(2019). In: British Society for Immunology (BSI) Congress 2019, 02-05 Dec 2019 :Liverpool, U.K.
Monocyte-derived microparticles activate human monocytes and promote their transendothelial migration
Luckhurst, Natasha, Hunter, Patricia, Freestone, Nicholas, Klein, Nigel and Arrigoni, Francesca(2019). In: British Society for Immunology (BSI) Congress 2019, 02-05 Dec 2019 :Liverpool, U.K.
Adenosine deaminase 2 promotes growth and migration of blood outgrowth endothelial cells, in the presence of adenosine
Halliday, L., Brogan, P., Freestone, N. and Arrigoni, F.(2019). 01 Nov 2019 : Kingston upon Thames, U.K.
Embedding critical thinking skills in the scientific curricula : how good are we?
Arrigoni, Francesca, Micallef, Ricarda and Wason, Hilary(2019). In: Horizons in STEM Higher Education Conference : Making Connections and Sharing Pedagogy, 03 -04 Jul 2019 :Kingston upon Thames, U.K.
Inflammatory phenotypes predict pulse wave velocity change on ART in Malawian adults
Kelly, Christine, Tinago, Willard, Garcia Abner, Alejandro, Hunter, Patricia, Alber, Dagmar, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Kamngona, Ralph, Mallon, Patrick, Mwandumba, Henry, Walker, Sarah, Khoo, Saye and Klein, Nigel(2019). In: Conference on Retroviruses and Opportunistic Infections (CROI) 2019, 04-07 Mar 2019 :Seattle, U.S.
Alterations in cellular microparticle levels as a marker of cellular activation and injury in children with HIV infection
Luckhurst, N., Kenny, J., Hunter, P., Freestone, N., Klein, N. and Arrigoni, F.(2018). In: 36th Annual European Society of Infectious Diseases (ESPID) Meeting : Advances in Paediatric Infectious Diseases, 28 May - 02 Jun 2018 :Malmo, Sweden
A tale of three faculties : addressing student's barriers to critical thinking using a collaborative learning and teaching approach
Wason, Hilary, Whiting, Cheryl and Arrigoni, Francesca(2018). 24-25 Apr 2018 : Glasgow, U.K.
How do we transform our students critical thinking abilities?
Wason, Hilary, Whiting, Cheryl and Arrigoni, Fran(2017). In: St George's, University of London's Education Day 2017 : Transformation, 15 Nov 2017 :London, U.K.
Transforming our teaching : using the Critical Thinking Skills Toolkit
Wason, Hilary, Whiting, Cheryl and Arrigoni, Fran(2017). In: St George's, University of London's Education Day 2017 : Transformation, 15 Nov 2017 :London, U.K.
Gallery of work
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Collecting the Athena SWAN award with Sir Paul Nurse
The Athena SWAN Bronze award for LSPC
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Alterations in cellular microparticle levels as a marker of cellular activation and injury in children with HIV infection
N. Luckhurst, PhD student of Dr Arrigoni, delivering her findings at ESPID (European Society for Paediatric Infectious Diseases), May 2018
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BPS Edinburgh 2019 successes!
PhD students old (Blerina Ahmetaj Shala- Bulbring Award ) and new (Loryn Halliday Tocris Travel Award) collect awards , and I meet up with my PhD supervisor Jane Mitchell
