Dr Terry Gaymes

Article

Gopal, Ajay K, Popat, Rakesh, Mattison, Ryan J, Menne, Tobias, Bloor, Adrian, Gaymes, Terry, Khwaja, Asim, Juckett, Mark, Chen, Ying, Cotter, Matthew J and Mufti, Ghulam J (2021) A Phase I trial of talazoparib in patients with advanced hematologic malignancies. International Journal of Hematologic Oncology, 10(3), IJH35. ISSN (print) 2045-1393

Gaymes, Terry J., Mohamedali, Azim, Eiliazadeh, Anthony L., Darling, David and Mufti, Ghulam J. (2017) FLT3 and JAK2 mutations in acute myeloid leukemia promote interchromosomal homologous recombination and the potential for copy neutral loss of heterozygosity. Cancer Research, 77(7), pp. 1697-1708. ISSN (print) 0008-5472

Mohamedali, A M, Gaken, J, Ahmed, M, Malik, F, Smith, A E, Best, S, Mian, S, Gaymes, T, Ireland, R, Kulasekararaj, A G and Mufti, G J (2015) High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS). Leukemia, 29(9), pp. 1928-1938. ISSN (print) 0887-6924

Gaymes, Terry J., Mohamedali, Azim M., Patterson, Miranda, Matto, Nazia, Smith, Alexander, Kulasekaraj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney and Mufti, Ghulam J. (2013) PARP inhibitor sensitivity in high risk MDS and acute myeloid leukaemia is associated with microsatellite instability dependent frameshift mutations in DNA repair genes. Haematologica, 98(9), pp. 1397-1406. ISSN (print) 0390-6078

Orr, S J, Gaymes, T, Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, G J, Marcotte, E M and Thomas, N S B (2010) Reducing MCM levels in human primary T cells during the G0-G1 transition causes genomic instability during the first cell cycle. Oncogene, 29(26), pp. 3803-3814. ISSN (print) 0950-9232

Gaymes, Terry J., Shall, Sydney, MacPherson, Lee J., Twine, Natalie A., Lea, Nicholas C., Farzaneh, Farzin and Mufti, Ghulam J. (2009) Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Acta Haematologica, 94, pp. 638-646. ISSN (print) 0001-5792

Gaymes, Terry J., Shall, Sydney, Farzaneh, Farzin and Mufti, Ghulam J. (2008) Chromosomal instability syndromes are sensitive to Poly ADP-ribose polymerase inhibitors. Haematologica, 93, pp. 1886-1889. ISSN (print) 0390-6078

Ranuncolo, Stella Maria, Wang, Ling, Polo, Jose M., Dell'Oso, Tania, Dierov, Jamil, Gaymes, Terry, Rassool, Feyruz, Carroll, Martin and Melnick, Ari (2008) BCL6 mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a 53-dependent pathway in a cell-context dependent manner. The Journal of Biological Chemistry, 283(33), pp. 22565-22572. ISSN (print) 0021-9258

Rassool, Feyruz, Gaymes, Terry J., Omidvar, Nader, Brady, Nicola, Buerlet, Stephanie, Pla, Marika, Reboul, Murielle, Lea, Nicholas, Chomienne, Christine, Thomas, Nicholas S.B., Mufti, Ghulam J. and Padua, Rose Ann (2007) Reactive oxygen species, DNA damage, and error-prone repair : a model for genomic instability with progression in myeloid leukemia? Cancer Research, 67(18), pp. 8762-8771. ISSN (print) 0008-5472

Gaymes, Terry J., Padua, Rose Ann, Pla, Marika, Orr, Steven, Omidvar, Nader, Chomienne, Christine, Mufti, Ghulam J. and Rassool, Feyruz V. (2006) Histone Deacetylase Inhibitors (HDI) cause DNA damage in leukemia cells : a mechanism for leukemia-specific HDI-dependent apoptosis? Molecular Cancer Research, 4(8), pp. 563-573. ISSN (print) 1541-7786

Brady, Nicola, Gaymes, Terry J., Cheung, Manyee, Mufti, Ghulam J. and Rassool, Feyruz V. (2003) Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins. Cancer Research, 63(8), pp. 1798-1805. ISSN (print) 0008-5472

Gaymes, Terry J., Mufti, Ghulam J. and Rassool, Feyruz V. (2002) Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer. Cancer Research, 62(10), pp. 2791-2797. ISSN (print) 0008-5472

Gaymes, Terry J, North, Phillip S, Brady, Nicola, Hickson, Ian D, Mufti, Ghulam J and Rassool, Feyruz (2001) Increased error-prone non homologous DNA end-joining - a proposed mechanism of chromosomal instability in Bloom's Syndrome. Oncogene, 21, pp. 2525-2533. ISSN (print) 0950-9232

Gaymes, Terry J, Cebrat, Marek, Siemion, Ignacy Z and Kay, John E (1997) Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation. FEBS Letters, 418(1-2), pp. 224-227. ISSN (print) 0014-5793

Book Section

Shall, Sydney, Gaymes, Terry, Farzaneh, Farzin, Curtin, Nicola and Mufti, Ghulam J. (2011) The use of PARP inhibitors in cancer therapy : use as adjuvant with chemotherapy or radiotherapy ; use as a single agent in susceptible patients ; techniques used to identify susceptible patients. In: Tulin, Alexei V., (ed.) Poly(ADP-Ribose) Polymerase: Methods and Protocols. New York, NY : Springer. pp. 239-266. (Methods in Molecular Biology) ISBN 9781617792700

Conference or Workshop Item

Gaymes, Terry, Carrett, Neil, Patel, Nishith, Kay, John and Siemion, Iggy (1995) Effects of cyclolinopeptide A on T lymphocyte activation and peptidyl prolyl isomerase activity. In: Biochemical Society Transactions 656th Meeting; 11 - 15 Sep 1995, Dublin, Ireland. (Unpublished)