Dr Andrew Snabaitis

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Research

About

I studied pharmacology at King's College London (University of London) where I completed a BSc (Hons) in pharmacology with toxicology. This course had a 12 month extramural component which I spent at Beecham's Pharmaceuticals (Harlow, Essex) and developed an interest in cardiovascular research. Upon recommendation, I then joined the United and Medical Dental Schools (UMDS) in London as a research assistant with the view of embarking on several years of research and study towards a PhD in cardiovascular sciences. I was lucky enough to receive studentship funded by the British Heart Foundation and successfully completed my PhD in 1998. Since obtaining my PhD I spent 11 years as a post-doctoral research associate/fellow in the Division of Cardiovascular Research at King's College London. I was funded by several research grants obtained from the Dunhill Medical Trust and the Medical Research Council. My post-doctoral research career culminated in obtaining independent funding in the form of an Intermediate Research Fellowship from the British Heart Foundation, after which I joined Kingston University as a lecturer in pharmacology and physiology. Since arriving at Kingston University I have continued my research into heart disease which has been funded by the British Heart Foundation. My laboratory studies the role of type 2A serine/threonine protein phosphatase enzymes and their associated regulatory proteins at the cellular/molecular level in acute (ischaemia/reperfusion) and chronic (pressure overload) models of heart failure

Academic responsibilities

Associate Professor in Molecular Cardiology

Qualifications

  • PhD in Pharmacology from King's College London
  • BSc Pharmacology with toxicology (2:1) from King's College London

Research

Cardiac cellular and molecular biology has been my main research interest for many years, with a focus on the regulation of intracellular pH in adult ventricular cardiac cells. More recently, I have developed an interest in the role(s) of the serine/threonine type 2A protein phosphatases and their associated regulatory proteins in laboratory models of acute (ischaemia/reperfusion injury) and chronic (pressure overload-induced hypertrophy) heart failure. 

Publications

Jump to: Article | Conference or Workshop Item
Number of items: 10.

Article

Paulsson-Habegger, Lukas, Snabaitis, Andrew K. and Wren, Stephen P. (2021) Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection. Bioorganic & Medicinal Chemistry, 48, p. 116389. ISSN (print) 0968-0896

Cowan, Jonathan, Longman, Michael R. and Snabaitis, Andrew K. (2021) Regulation of cardiomyocyte DNA damage and cell death by the type 2A protein phosphatase regulatory protein alpha4. Scientific Reports, 11, p. 6293. ISSN (online) 2045-2322

Eleftheriadou, Olga, Boguslavskyi, Andrii, Longman, Michael R., Cowan, Jonathan, Francois, Asvi, Heads, Richard J., Wadzinski, Brian E., Ryan, Ali, Shattock, Michael J. and Snabaitis, Andrew K. (2017) Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy. Basic Research in Cardiology, 112(37), pp. 1-18. ISSN (print) 0300-8428

da Silva, RAG, Churchward, CP, Karlyshev, AV, Eleftheriadou, O, Snabaitis, AK, Longman, MR, Ryan, A and Griffin, R (2017) The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of Factor H binding protein of ' Neisseria meningitidis ' strain MC58 and its potential as a drug target. British Journal of Pharmacology, 174(14), pp. 2247-2260. ISSN (print) 0007-1188

Longman, Michael R., Ranieri, Antonella, Avkiran, Metin and Snabaitis, Andrew K. (2014) Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory Class G-Protein coupled receptors in cardiomyocytes. PloS one, 9(1), e86234. ISSN (online) 1932-6203

Vila-Petroff, Martín, Mundiña-Weilenmann, Cecilia, Lezcano, Noelia, Snabaitis, Andrew K, Huergo, María Ana, Valverde, Carlos A., Avkiran, Metin and Mattiazzi, Alicia (2010) Ca2+/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na+/H+ exchanger activation. Journal of Molecular and Cellular Cardiology, 49(1), pp. 106-112. ISSN (print) 0022-2828

Kato, Koji, Yasutake, Masahiro, Dalin, Jia, Snabaitis, Andrew K, Avkiran, Metin, Kusama, Yoshiki, Takano, Teruo and Mizuno, Kyoichi (2010) Urotensin II activates Sarcolemmal Na+/H+ exchanger in adult rat ventricular Myocytes. Journal of Cardiovascular Pharmacology, 55(2), pp. 191-197. ISSN (print) 0160-2446

Snabaitis, Andrew K., Cuello, Friederike and Avkiran, Metin (2008) Protein Kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1. Circulation Research, 103(8), pp. 881-890. ISSN (print) 0009-7330

Conference or Workshop Item

Eleftheriadou, Olga, Boguslavskyi, Andrii, Ryan, Ali, Shattock, Michael J, Wadzinski, Brian E and Snabaitis, Andrew K (2015) Expression of type 2A protein phosphatases in cardiac health and disease. In: 33rd Meeting of the International Society for Heart Research-European Section; 01 - 04 Jul 2015, Bordeaux, France.

Eleftheriadou, O, Longman, MR, Boguslavskyi, A, Ryan, A, Wadzinski, BE, Shattock, MJ and Snabaitis, AK (2014) Expression of type 2A protein phosphatases in cardiac health and disease. In: 2014 Autmun Meeting British Society for Cardiovascular Research; 08 - 09 Sep 2014, Reading, U.K..

This list was generated on Sat Dec 21 03:48:40 2024 GMT.