Neurons in the brain malfunction and degenerate in dementia. Microglia have been shown to be overactive in the brains of people with dementia leading to chronic inflammation with consequential neurodegeneration. Additionally, both dementia and neuroinflammation are strongly linked to metabolic dysregulation. Recent studies have suggested neuronal proteins may have a causative role in activating inflammatory cells in peripheral fat tissue. This project aims to investigate these proteins and their role within microglial biology. The results may give suggestions on how to reduce the nerve cell damage associated with dementia.
In 2022 I successfully obtained a First Class BSc (Hons) Biochemistry degree at Kingston University London. Having worked on the genetic expression of neuronal proteins as my final year dissertation project, I found myself diving into the field of neurodegenerative diseases. Continuing within the same field, I received an opportunity to pursue an MSc by Research at Kingston University London to investigate microglial biology with Dr Mackenzie and Dr Stolinski.