Mrs Sravani Emani
Contact
- Email: k1933879@kingston.ac.uk
- Location: Penrhyn Road
- Faculty: Faculty of Engineering, Computing and the Environment
- School: School of Life Sciences, Pharmacy and Chemistry
- Department: Department of Chemical and Pharmaceutical Sciences
Research project: The use of nano-carriers to selectively target mitochondria in cancer
Abstract
Drug carriers such as carbon nanotubes(CBTs) and liposomes can facilitate transport of drugs through cellular membranes. Covalent functionalisation provides an opportunity of tagging these delivery vessels with moieties that can provide selective targeting. One example is the use of mitochondriotropics such as delocalised lipophilic cations (DLC), which have been demonstrated to selectively accumulate inmitochondria of cancer cells as opposed to normal ones.
Hence, this study proposes the preparation of novel delivery systems (such as hydrogels, CNTs or liposomes) incorporating boronated drugs and whose surface has been functionalised with dyes that can afford more selective targeting strategies.
- Research degree: PhD
- Title of project: The use of nano-carriers to selectively target mitochondria in cancer
- Research supervisor: Dr Gianpiero Calabrese
- Other research supervisor: Dr Anil Vangala
Biography
I have done my Masters in Medicinal Chemistry from India. Worked as a Research Assistant in the lipid division under the guidance of Dr. B.V.S.K.Rao at the Indian Institute of Chemical Technology. This helped me gain interest in research areas, especially in Nanosciences. I am a third-year PhD student, a self-motivated researcher working in the field of drug delivery. Currently, I am working on polymeric hydrogels and nanoparticles that can be used in targeted drug delivery for the potential treatment of brain tumors. Expertise in analytical and spectroscopic techniques (HPLC, NMR, FTIR, DSC, TGA, UV-Vis, SEM, LC-MS, texture analyzer, rheometer).
Areas of research interest
- Polymers
- Drug chemistry
- Nanocarriers (liposomes, CNT)
- Hydrogels
- Cancer research - solid tumour (Glioblastoma multiforme)
Qualifications
- Bachelors in Pharmacy
- Masters in Pharmaceutical chemistry
Funding or awards received
- Registered Pharmacist - Pharmacy council of India
- AFHEA (Associate Fellowship) - Issued by Higher Academy 2021
- Faculty achievement award, Spring 2023
Publications
Pharmaceutics | Free Full-Text | Chitosan Hydrogels Cross-Linked with Trimesic Acid for the Delivery of 5-Fluorouracil in Cancer Therapy (mdpi.com)
Jump to: Article
Number of items: 1.
Article
Emani, Sravani, Vangala, Anil, Buonocore, Federico, Yarandi, Niousha and Calabrese, Gianpiero (2023) Chitosan hydrogels cross-linked with trimesic acid for the delivery of 5-fluorouracil in cancer therapy. Pharmaceutics, 15(4), p. 1084. ISSN (online) 1999-4923