The role of the Hippo pathway in the regulation of organ growth is anextensively studied field however the metabolic processes which canregulate this pathway are relatively unknown. The dysregulation ofmetabolic pathways are fundamental to disease processes in cancer,obesity and diabetes. The Hippo pathway is a key growth controlpathway which when deregulated allow the activation of the pro-growthprotein YAPallowing its translocation to the nucleus to promotetranscription of pro proliferative and anti-apoptotic genes. There isgrowing evidence that manipulation of metabolism by affecting cellularglucose and lipid metabolism could affect the activation of YAP/TAZ.This project aims to elucidate the molecular link between metabolismand disease by manipulating the hippo pathway
I studied BSc Biochemistry at University of Essex then completed my Masters degree at University College London (UCL)